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KMID : 1134120150180030279
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Journal of Breast Cancer
2015 Volume.18 No. 3 p.279 ~ p.284
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Prognostic Factors for Distant Metastasis in Patients with Locoregional Recurrence after Mastectomy
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Jeong Yu-Ri
Kim Su-Ssan
Gong Gyung-Yub
Lee Hee-Jin
Ahn Sei-Hyun
Son Byung-Ho
Lee Jong-Won
Choi Eun-Kyung
Lee Sang-Wook
Ahn Seung-Do
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Abstract
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Purpose: The purpose of this study was to identify patients with high risk of distant metastasis (DM) after salvage treatment for postmastectomy locoregional recurrence (LRR).
Methods: We retrospectively reviewed 142 patients who received salvage radiotherapy with or without wide excision for isolated LRR after mastectomy between January 1999 and December 2012. Distant metastasis-free survival (DMFS) was estimated from the date of diagnosis of isolated LRR to the date of DM or last follow-up using the Kaplan-Meier method, and Cox regression analysis was performed to identify prognostic factors for DM.
Results: The median follow-up period was 54 months. The major failure pattern was DM (56%) and the 5-year DMFS was 43%. In multivariate analysis, initial N (iN) stage, recurrent N (rN) stage, and hormone receptor (HR) status were significant prognostic factors for DM (5-year DMFS: iN0 vs. iN1-3, 73% vs. 25%, p<0.001; rN0 vs. rN1-3, 61% vs. 29%, p<0.001; HR+ vs. HR-, 49% vs. 21%, p<0.001).
Conclusion: Patients with lymph node involvement and/or HR- specimens seem to experience more DM than patients with chest wall-only recurrence and HR+ specimens. Further studies are needed to investigate the role of chemotherapy in these patients.
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KEYWORD
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Breast neoplasms, Drug therapy, Local neoplasm recurrence, Mastectomy, Neoplasm metastasis
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